Voltage-dependent gating of an asymmetric gramicidin channel.
نویسندگان
چکیده
منابع مشابه
Voltage-dependent behavior of a "ball-and-chain" gramicidin channel.
The channel-forming properties of two analogs of gramicidin, gramicidin-ethylenediamine (gram-EDA), and gramicidin-N,N-dimethylethylenediamine (gram-DMEDA) were studied in planar lipid bilayers, using protons as the permeant ion. These peptides have positively charged amino groups tethered to their C-terminal ends via a linker containing a carbamate group. Gram-DMEDA has two extra methyl groups...
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The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable point mutation that confers significant voltage dependence to Kir6.2, a ligand-gated channel that lacks any canonical voltage-sensing domain. Simil...
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I N T R O D U C T I O N Many K§ channels are inhibited by Ba ions. In the cases for which careful mechanistic studies have been carr ied out (Armstrong and Taylor , 1980; Eaton and Brodwick, 1980; Armst rong et al., 1982; Vergara and Latorre , 1983), the evidence argues that the Ba ion acts via a simple blocking scheme; it enters the conduct ion pathway o f the K § channel, where it binds tight...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.6.2121